Modified cells as potential ocular drug delivery systems

Microemulsions as potential ocular drug delivery systems: phase diagrams and physical properties depending on ingredients.

The microemulsion systems, both o/w and w/o, composed of isopropyl myristate, soybean lecithin (Epikuron 200), Polysorbate 80, Cremophor EL, n-butanol and triacetine, taken at various amounts and in various combinations, were tested in order to assess their physical-chemical properties. Some ingredients of the microemulsions were physiologically acceptable, except one formulation containing n-b...

Liposomes as Potential Drug Carrier Systems for Drug Delivery

Pluronic as nano-carier for drug delivery systems

A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such mater...

Recent Advances in Ocular Drug Delivery Systems

Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced ...

Ocular drug delivery systems: An overview.

The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal, dynamic and static ocular barriers. Also, therapeutic dru...